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nitric oxide gas

The body's metabolic processes result in the release of nitric oxide gas. It is generated as a result of a reaction between the cells of the body and molecules of nitric oxide. Nitric oxide is produced as a byproduct of this reaction. Nitric oxide is a potent gas that has various impacts that are to our advantage. It has the potential to alleviate stress, enhance blood flow, and assist with maintaining heart health. Additionally, it can be utilized in the treatment of respiratory failure in infants.

Metabolism of nitric oxide gas in neonates with respiratory failure

The metabolic processes of nitric oxide gas in babies with respiratory failure have been the subject of investigation in a number of prospective randomized controlled trials. In these research, the effects of iNO on oxygenation and absorption into the circulation have been the primary areas of investigation. It has been demonstrated that these findings are significant for a potential extra advantage offered by iNO therapy. In addition, the results of these studies give evidence for a potential mechanism through which iNO may enhance the clinical fate of premature infants who are suffering from respiratory failure.


Newborns with birth weights between 500 and 799 g were enrolled in the NO CLD experiment, which was a randomized, placebo-controlled trial. The infants were given a random assignment to receive either iNO or a placebo. After receiving treatment for a period of twenty-four days, the neonates were examined. Following the first three days, samples of TA and plasma were obtained in order to analyze NO and its metabolites. These metabolites are used as an index to measure the amount of NO that is delivered into the lungs, and are therefore classified as biomarkers for NO.


Plasma NOx concentrations were considerably greater in the infants who were given treatment compared to the infants who served as controls. The mean plasma NOx concentration of babies who were administered with iNO was 4.25 +/- 1.75 mM at 20 post-primary minutes, whereas the concentration of NOx in the control group was 2.15 +/- 1.33 mM. A higher increase in NOx and nitrite concentrations was seen in the infants who were given iNO treatment both during the treatment process and at the time of collection.


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